Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in …
OBJECTIVE: The identification of sensitive biomarkers is essential to validate therapeutics for Huntington's disease (HD). We directly compare structural imaging markers across the largest collective imaging HD dataset, to identify a set of imaging …
Abstract Introduction This work aims to characterize the sequence in which cognitive deficits appear in two dementia syndromes. Methods Event-based modeling estimated fine-grained sequences of cognitive decline in clinically-diagnosed posterior …
The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning …
See Li and Donohue (doi:10.1093/brain/awy089) for a scientific commentary on this article. Dominantly-inherited Alzheimer's disease is widely hoped to hold the key to developing interventions for sporadic late onset Alzheimer's disease. We use …
We demonstrate the use of a probabilistic generative model to explore the biomarker changes occurring as Alzheimer's disease develops and progresses. We enhanced the recently introduced event-based model for use with a multi-modal sporadic disease …