Computational models for clinical trial design in Huntington’s disease

  • Funding: UK Medical Research Council.
  • Dates: Sep 2019 – Aug 2022.
  • Personnel: Peter Wijeratne (Fellow).
  • Summary: Pete’s MRC Skills Development Fellowship aims to change the way disease modifying therapies in Huntington’s Disease are developed by designing early-phase clinical trials around computational models of disease progression. The project takes a two-step approach: first, redefine phenotypes using machine learning techniques applied to large multi-centre cohort data; second, use model-based analysis of multi-modal data – properly informed by the underlying biology – to reveal the disease mechanisms driving the observed phenotypes, and identify key biomarkers.
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