Personnel: Chris Parker, Dave Cash, Alex Young, Peter Wijeratne (U Sussex), Neil Oxtoby (PI).
Summary: This project uses POND models to analyse autosomal dominant Alzheimer’s disease, investigating the relation between disease progression, biomarker evolution, genotype, and cognitive performance. Key outputs include data-driven sequences of disease progression, subtype genetic profiles, cognitive performance trajectories, and early pre-symptomatic biomarkers.
